What is Mesotherapy?

Mesotherapy is a technique, invented in 1952 by Dr. Michel Pistor, whereby medication is injected into the mesoderm, the layer of fat and connective tissue under the skin. Over the past 50+ years in excess of 15, 000 physicians world-wide have used Mesotherapy on a daily basis for a variety of purposes, including overall weight reduction, cellulite reduction, hair loss, scar revision and wrinkle elimination.

In 1987, the French Academy of Medicine recognized Mesotherapy as an inherent part of traditional medicine. The International Society of Mesotherapy encompasses 14 countries throughout Europe and South America.

In Mesotherapy, very small doses of a medication called deoxycholate are administered in specific areas, depending on the conditions being treated. Deoxycholate is Health Canada and FDA approved and is obtained from local pharmaceutical companies.

How does Mesotherapy work?

The deoxycholate breaks down the fat beneath the skin and shrinks the fat cells in Scarpa’s fascia layer. The fat dissolves and, as occurs when fat is broken down during typical weight loss, is carried through the bloodstream and excreted by the kidneys and bowel. To enhance the absorption of fat, a multivitamin injection can be given intramuscularly.
Cellulite is caused by connective tissue bands that hold down the skin, trapping the fat and thereby causing a “dimpling” effect. The deoxycholate destroys the connective tissue bands and melts the trapped fat, creating a smooth, dimple-free appearance.

What is the treatment like?

Using a very tiny needle (0.3 mm or the size of an eyelash), the medication is injected painlessly into the mesoderm. Expect to feel some burning and or discomfort for 20 minutes after treatment. There may also be some lingering pain experienced for 48 hours after treatment. In such cases, use a non anti-inflammatory pain reliever such as Tylenol for discomfort.

All patients undergoing Mesotherapy will be asked to follow a natural healthy diet. Because toxins are eliminated, lots of water is required to flush these substances, along with dissolved fat, out of the body. Exercise is needed to circulate the medications used. We recommend walking or another form of aerobic activity, at least three times a week.

Who can have Mesotherapy?

Any adult between the ages of 18 – 75 and in good health can be a candidate for Mesotherapy for weight loss, spot weight reduction, and cellulite reduction. During the initial consultation, we will review your past and present medical conditions as well as any medications being taken. Please see the following paragraph for those who are NOT candidates for Mesotherapy.

Who cannot have Mesotherapy?

Pregnancy or nursing is an absolute contraindication.

Relative contraindications include:

  • Patients that are insulin-dependent diabetics.
  • Patients with a history of stroke.
  • Patients with a history of recent cancer.
  • Patients with a history of blood clots.
  • Patients who are on multiple medications for heart disease.

For Cellulite

Mesotherapy is a solution that can eliminate dimpling fat under the skin. Cellulite is an accumulation of fat, fluid, and toxins trapped in a hardened network of connective tissue fibers in the mesoderm layer. Lymphatic and venous circulation is poor in these areas. Mesotherapy is used to cause an increase in venous and lymphatic flow, as well as the elimination of fat and dimpling in the area. In four weeks, a patient’s skin can appear significantly smoother. Patients can lose anywhere from two to four inches where their cellulite is treated.

For spot fat reduction

Mesotherapy is an alternative to liposuction. Like liposuction, fat cells are eliminated from the targeted area. After 4-6 sessions, patients can lose two to six centimeters in their saddle bags, hips, thighs, waist, love handles, back fat and chin when medicine is placed in those areas.

What should be expected following a treatment?

There may be minor pain, throbbing and tenderness in the treated areas with some bruising.

How often can a treatment be done?

Mesotherapy is administered at 2-6 week intervals.

Will the fat in the treated areas return?

No, the dissolved fat has not been reported to return. But new weight gain can build up new fat cells. Exercise and diet in addition to Mesotherapy treatment have shown the best long term results.


Deoxycholic acid or deoxycholate is a compound used in mesotherapy treatment to break down localized fat deposits. Of all the products used to perform mesotherapy, deoxycholate is the most extensively studied.

Belkyra is a deoxycholate formulation developed and marketed by Allergan, specifically for the treatment of submental fat, ie, ‘double chin’. Early results have shown remarkable effectiveness for reduction of submental fat. It is contraindicated for patients who have a history of dysphagia (difficult swallowing) and should be used with caution in patients who have had prior surgical or esthetic treatment of the area. The relative contraindications to mesotherapy in other areas also apply to treatment of submental fat.